What is CBDA - Cannabidiolic Acid? A Prominent That’s Natural Cannabinoid!

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CBDA (short for cannabidiolic acid) is the raw predecessor molecule to CBD.  Over time, and/or when the oil from cannabis/hemp is heated, CBDA converts naturally to CBD.

Most cannabinoids bind directly to the CB1 or CB2 receptors in one’s Endocannabinoid System (ECS).  CBDA doesn’t work this way, instead, CBDA works within the ECS by inhibiting the COX-2 (cyclooxygenase-2) enzyme.   COX-2 enzymes are related to inflammation, they appear either after an infection or injury.  By blocking these COX-2 enzymes, CBDA can effectively relieve inflammation and the corresponding pain.

Research on CBDA has been taking place for about 10 years.  A study in 2008 compared the molecular structure of CBDA with NSAIDs (nonsteroidal anti-inflammatory drugs) and found that their chemical structures are very similar - both have the ability to inhibit COX-2 receptors - leading to anti-inflammatory qualities and possibilities.

Also, CBDA works on 5-HT receptors in a similar way as SSRIs (selective serotonin reuptake inhibitors) - meaning that CBDA could eventually work similar to an antidepressant medication.

One of the largest cannabis companies to research and file patents for both CBD and CBDA - GW Pharmaceuticals - has filed patents for the use of CBDA for inflammatory skin diseases and cancer treatment.

What does all this mean?  Preliminary research and anecdotal evidence are finding that CBDA may be as effective or even more effective than CBD for treating inflammation, pain, and depression among other common ailments.

That's Natural products contain a truly natural spectrum of cannabinoids, which includes CBDA!  Try them today!


If you want to experience the Entourage Effect, we believe it is imperative that you preserve the naturally occurring cannabinoids and terpenes that exist in healthy hemp plants.  To do this, would seem simple, but so many people in the industry have taken steps to refine and adulterate their product to make it “more potent”.  Nature’s potency isn’t qualified by quantity, but QUALITY.

At That’s Natural, we never take anything out of our oil and we never add anything back in - the CBD-rich (and other cannabinoids and terpenes as well) hemp oil that we use is raw.  We never use dangerous chemical solvents to refine our product and we never adulterate our oil with foreign-sourced terpenes.  WE NEVER USE CBD ISOLATE. Our product is as natural as you can get.

Leaving the CBD-rich oil in its natural raw form allows the intelligence and abundance of nature to work her magic using the precious plant compounds that exist in these Colorado hemp plants!  Nature knows how to build immunity and strength, and that is what matters for your Endocannabinoid System!

You will see, smell, taste, and FEEL the difference, as noted by our thousands of customers across the country.  Again - it isn’t about QUANTITY, it is about QUALITY.  That’s Natural products are raw, pure, potent, and trusted.  We hope you will give them a try!