The Veteran's Association and Its Take on CBD

| in PTSD, Veterans |

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When it comes to PTSD and veterans, no one is more familiar with that combination than the Veteran’s Association. They deal with over 9 million veterans nationwide. So, what is their stance on CBD and PTSD?

This article from the VA shows beneficial uses for PTSD. It states that, “However evidence indicated that the CBD lessens anxiety best “in subjects where stress had been caused before CBD administration.” This means that CBD is ideal for those who get anxious from experiences, situations, or in random moments. Therefore, veterans currently suffering from PTSD who get random episodes of significant anxiety could get relief using CBD oils after each traumatic incident.”

This article continued on saying that one of the studies it examined showed, “that “in a sub chronic study, CBD administered daily 1 hour after predator stress (a proposed model of PTSD) reduced the long-lasting anxiogenic effects of chronic predator stress, partially via 5-HT1AR activation.” In an additional study of chronic anxiety, systemic CBD “prevented increased anxiety produced by chronic unpredictable stress, in addition to increasing hippocampal AEA.”

Finally, the VA concluded with this statement:

“The study found the use of CBD to be the most effective in helping people deal with traumatic events. What this means is that Veterans, combat soldiers, or other people alike can probably use CBD within an hour of their experience, and significantly decrease the adverse effects of the disorder. This is extremely important because if this is, in fact, the case, CBD oil products can be revolutionary for the military and VA in terms of managing such issues. This is not a ‘solution’ or a “remedy” because CBD won’t make the symptoms go away. However, with regular CBD use, managing the issues of PTSD and post-war anxiety will be more comfortable.

There is also a possibility that CBD may be even more beneficial for active members of the military in combat. No evidence explicitly affirms this; however, it is likely that using CBD while on active duty could probably decrease the development of PTSD and severe anxiety before it’s too late. In other words, the immediate use of CBD oils or other products when active duty soldiers feel anxious, or PTSD may help reduce their anxiety symptoms and put them in a less depressive or anxious state overall. Using CBD products early enough could prevent severe PTSD or anxiety from entirely developing.”

Furthermore, the National Institutes of Health (NIH) says that CBD can actually help veterans forget traumatic experiences, due to its relationship with the endocannabinoid system (eCB).

“In a systematic search of the extant literature for original articles on the molecular pharmacology of CBD, we found a study by Ibeas Bih et al. (2015), which suggested that CBD was unlikely to exert its effects in neurological diseases through modulation of the eCB system. The authors show that CBD can act through 65 discrete, specific molecular targets, including 10 receptors, 32 enzymes, 10 ion channels, and 13 transporters. With regard to the possible modulation of the eCB system, a study published by Massi et al. (2008) showed that CBD stimulated (rather than inhibited, as previously proposed) FAAH, which is involved in the catabolism of AEA; reports of CBD effects on this target are conflicting in the literature. In addition, inhibition of FAAH by CBD in vitro is only manifested at high concentrations, which may be difficult to achieve in vivo, given the relatively poor bioavailability of CBD (Ibeas Bih et al., 2015). Nevertheless, because FAAH activity appears to be increased by chronic restraint stress in animal models as well as by anxiety-like behaviors (Hill et al., 2013b), FAAH inhibition by CBD appears to us as a possible alternative to explain the CBD effects in aversive memories. In any case, a great deal of caution is needed when interpreting in vitro assays and, especially, when extrapolating in vitro results to the in vivo effects of CBD. Taking into account a possible inhibitory effect of high doses of CBD on the FAAH transporter, it appears likely that incomplete inhibition of FAAH by CBD underlies at least some of its effects in vivo (Bisogno et al., 2001De Petrocellis et al., 2011). This mechanism may be the most promising possibility to explain at a molecular level the inhibitory effects of CBD on behavioral responses related to the recall of traumatic events and it is worth further investigation.

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