The Entourage Effect and Migraines

| in Entourage Effect, Head Pain, Research |

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Migraines. From bad headaches, to more severe ones mimicking a stroke by impacting ones sensory, motor, or verbal abilities. Nonetheless, for anyone that’s had a migraine, they know it’s far from a pleasant experience. Migraines are the 3rdmost prevalent illness in the world, and 6thmost disabling illness in the world. These stats show just how serious the condition is, and was found by the Migraine Research Foundation.


This study from the NIH helps understand that it’s not really limited to just one or two cannabinoids or terpenes that may help those that suffer from migraines. It says:

In summary, cannabinoids – due to their anticonvulsive, analgesic, antiemetic, and anti-inflammatory effects – present a promising class of compounds for both acute and prophylactic treatment of migraine pain. In view of the rapidly unfolding changes in the legal status of cannabis, research on (endo)cannabinoids has become pertinent once again. Formal approval of a cannabinoid-based drug for other pathologies opens a possibility for repurposing these agents also to treat migraine. The abundance of CB1 receptors in the brain makes them an attractive target for treatment of migraine via blocking not only peripheral but also the central nociceptive traffic and reducing the pathologically enhanced cortical excitability predisposing to CSD. CB2 receptors in immune cells can be targeted to reduce the inflammatory component associated with severe forms of migraine. Exogenous compounds lacking the unwanted peripheral pro-nociceptive component or eCBs generated via inhibited degradation pathways and combined with other supportive agents are most desirable for this aim. Moreover, primary stratification of patients to identify and predict the effectiveness of cannabinoid treatment can greatly improve the efficiency of this approach.


Another study from the NIH shows how effective terpenes β-caryophyllene and β-myrcene

can also be in relieving migraines. It even went as far as to say that strains of cannabis that are predominant in those terpenes are the most desirable for migraines and headaches. It continued on to say:

“This could reflect the potent analgesic, anti-inflammatory, and anti-emetic properties of THC, with anti-inflammatory and analgesic properties of β-caryophyllene and β-myrcene. Opiates/opioids were most commonly substituted with cannabis. Prospective studies are needed, but results may provide early insight into optimizing crossbred cannabis strains, synergistic biochemical profiles, dosing, and patterns of use in the treatment of headache, migraine, and chronic pain syndromes.” 

Given these studies, and many more, there is reason to believe that CBD, and the other prominent cannabinoids and terpenes in That’s Natural’s products, would be cause to believe that, although they likely wouldn’t completely alleviate migraines or their symptoms, could be a very viable option for some people.

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