Entourage Effect: Humulene and CBD

| in Full Spectrum, Terpenes |

hemp-derived CBD, legal hemp CBD, The That’s Natural terpene profile includes: beta-myrcene, linalool, d-limonene, alpha-pinene, humulene, beta-caryophyllene - more from Thats Natural at www.cbdoil.life, cbdoil.life, and www.thatsnatural.info and find us an our Life Force Market outside of Basalt, Colorado in the Aspen Valley next to the Willits Gas Station CBD Distillery, best-rated CBD, Alex Jones, Glenn Beck, CW Botanicals #ThatsNatural #lifeforce #cbd #cbdoil

The Entourage Effect is becoming more and more of a researched and intriguing concept. It’s basically the enhanced impact that multiple cannabinoids and/or terpenes have when working together. Let’s take a look at one of the main ways that Humulene (a prominent terpene) and CBD work together.

Inflammation is one of the primary causes of pain. This is good news and bad news. The bad news is that it is so prominent. The good news is that there are terpenes and cannabinoids that can potentially reduce this inflammation, which would reduce the pain. This article from the National Institutes of Health (NIH) explains how powerful Humulene is as an anti-inflammatory agent. It says:

Systemic treatment with alpha-humulene largely prevented both tumor necrosis factor-alpha (TNFalpha) and interleukin-1beta (IL-1beta) generation in carrageenan-injected rats, whereas (-)-trans-caryophyllene diminished only TNFalpha release. Furthermore, both compounds reduced the production of prostaglandin E(2) (PGE(2)), as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) expression, induced by the intraplantar injection of carrageenan in rats. The anti-inflammatory effects of alpha-humulene and (-)-trans-caryophyllene were comparable to those observed in dexamethasone-treated animals, used as positive control drug. All these findings indicate that alpha-humulene and (-)-trans-caryophyllene, derived from the essential oil of C. verbenacea, might represent important tools for the management and/or treatment of inflammatory diseases.

Meanwhile, CBD has probably been studied most for its anti-inflammatory properties. It states:

This study showed for the first time that local CBD administration inhibited pain and peripheral sensitisation in established OA. Topical treatment with CBD reduced leukocyte trafficking and joint hyperaemia during the early stages of MIA. By attenuating this initial inflammatory response with CBD, end-stage OA pain and peripheral neuropathy were abrogated. Thus, CBD may be a safe therapeutic to treat OA pain locally as well as block the acute inflammatory flares that drive disease progression and joint neuropathy.

These studies again show the power of using a full-spectrum product, as opposed to an isolated product of CBD. Our suggestion is to take the time to research a product, find out where it’s grown, what the other ingredients are, find out its purity, if it is independently verified and tested, and also whether it is full-spectrum.  


So many CBD products on the market are complete junk.  Hundreds of people and companies have “jumped in” by simply white-labeling product that has zero traceability and is completely full of un-knowns.  Unknown origin of product (so much CBD oil and CBD isolate is coming from China).  Unknown traceability of supply chain.  Unknown type of extraction and solvents used.  Unknown testing for pesticides, heavy metals, and chemical solvents. Unknown combinations of cannabinoids and terpenes that have been artificially added back in.  A lot of unknowns can add up to  products that either don’t help people or worse - make people feel sick because of the potential chemicals and pesticides in them.

At That’s Natural, we are not your average CBD product.  First of all, we have been in business for over 14 years in Colorado and have a proven track-record of serving customers.  Secondly, we control our entire supply chain - we know our farmers personally, we know our extractors personally, and we control the oil from the moment it is out of the extractor, through all formulations, until the product reaches store shelves or our customers direct.

We never take anything out of our raw CBD Oil and we never add anything artificial back in.  That means that we can guarantee there are no chemical solvents and that you are getting the NATURAL and UNIQUE cannabinoids and terpenes that were originally a part of our very healthy Colorado hemp plants.  We test our oil to ensure and prove what it is.

This is a big deal.  We believe in traceability and transparency, and we have customers all around the country who have used our products successfully.   Our marketing is word-of-mouth.  Our goal is to create the most pure and potent products by allowing Mother Nature to do what she does best.

Packed with love and life force - you will see, smell, taste, and feel the difference with our premium products.  If you have tried a CBD product with no positive result, we sure hope you will consider giving us a try!