Contributing Factors To Pain Relief/Inflammation

| in Education, Inflammation, Research |

Pain is one of the primary reasons people use CBD in this day and age. This article by Pharmacology & Pharmacy, from 2015, explains that full spectrum products are generally better received than those with pure CBD isolate in them. This is mainly because of what is known as the Entourage Effect. Full spectrum products, such as That’s Natural’s contain each compound found in the hemp plant – primarily cannabinoids and terpenes. Below are some of the major compounds that help customers with pain relief.


Beta-Myrcene is one of the primary cannabinoids found in hemp, and That’s Natural’s CBD hemp oil products. This study from the NIH stated “Since plant-derived mixtures of cannabinoids and the Cannabis component myrcene have been suggested as pain therapeutics, we screened terpenes found in Cannabis for activity at TRPV1.” What is TRPV1? The transient receptor potential cation channel subfamily V member 1, also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It continues on to say, “Since it seems likely that complex mixtures of cannabinoids and terpenes are likely to be of therapeutic importance, understanding which are likely to interact, compete or synergize also be facilitated by this approach. Our data show that Myrcene and CBD share elements of a binding site and can influence one another physiologically, for example.


Alpha-Pinene and Linalool:

Alpha-Pinene and Linalool are other prominent terpenes that are prevalent in That’s Natural’s full-spectrum products. This article from the NIH not only presents the belief that Alpha-pinene and Linalool is highly anti-inflammatory, but also presents more evidence for the belief in what the Entourage Effect is. It states:


“A study carried out to investigate the antinociceptive and anti-inflammatory action of frankincense oil and water extracts and three of its main componentes, i.e., linalool, α-pinene and 1-octanol, via xylene-induced ear edema and a formalin-inflamed hindpaw model in male Kunming mice, showed consistent evidence about their anti-inflammatory and analgesic effects. Frankincense oil extract, which contains more linalool, α-pinene and 1-octanol than frankincense water extract, produced a faster and more effective reduction of the swelling and pain than the water extract. In addition, the combination of linalool, α-pinene and 1-octanol exhibited stronger biological effect on hindpaw inflammation and COX-2 overexpression than the three compounds used separately, indicating that they contribute to the topical antinociceptive and anti-inflammatory properties of frankincense by inhibiting COX-2 activation [64].”



Cannabigerol (CBG) is a major cannabinoid found in hemp. It also has been studied for pain-relief. Again, as with most of these compounds, is found to have a more profound impact when used in combination with other cannabinoids. This study from the NIH says, “CBD and CBG also have analgesic and antiinflammatory effects, indicating that there is scope for developing drugs which do not have the psychoactive properties of THC.


These studies show why so many people are using full spectrum products, including That’s Natural’s to help with pain relief. Is it a guaranteed result? Absolutely not. However, with the safety profile of CBD and these other cannabinoids and terpenes, it’s a lot safer product to try than a lot of other more mainstream options.

That’s Natural hemp-derived CBD products – legal in all 50 States!  At That’s Natural, we make sure that we bring our customers a pure, potent, and effective product.  We do this through having complete control of our supply chain! We know our Colorado hemp farmers, we only use supercritical CO2 extraction and steam distillation – NEVER using chemical solvents or isolate, and we make sure that the products’s other ingredients are the highest quality possible!  Our process ensures a product that is full of NATURALLY occurring cannabinoids and terpenes – ensuring that our customers can experience the Entourage Effect!  Our products have life force – because at That’s Natural we truly care about helping our customers experience better well-being and an improved quality of life!  We hope you will try us out and experience a truly natural CBD Oil!  That’s Natural!